Receptor-mediated PLGA nanoparticles for glioblastoma multiforme treatment

• Type: Article in International Scientific Journal
• Date: 2018

Authors

Maria João Ramalho (Author) Other; E. Sevin (Author) Other; F. Gosselet (Author) Other; J. Lima (Author) Other; Manuel A. Coelho (Author) FEUP; Joana A. Loureiro (Author) FEUP; Maria do Carmo Pereira (Author) FEUP

Journal

Title: International Journal of Pharmaceutics

Vol. 545 No. 1-2

Pages: 84-92

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 66 Citations

Scopus - 66 Citations

Associated Projects

LEPABE - Laboratório de Engenharia de Processos, Ambiente, Biotecnologia e Energia

LEPABE-2-ECO-INNOVATION - LEPABE-2-ECO-INNOVATION

NanoEFEct - Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma

Other information

Authenticus ID: P-00Q-HJY

DOI: 10.1016/j.ijpharm.2018.04.062

Abstract (EN): Glioblastoma multiforme is the most lethal type of brain tumor and the established therapy only extends patients survival to approximately one year. Its first-line treatment is based on of chemotherapy with the alkylating agent temozolomide (TMZ). As many other chemotherapeutic drugs, TMZ presents several limitations as high toxicity and low bioavailability. The delivery of TMZ using poly(lactic-co-glycolic acid) nanoparticles is proposed in this work. Stable nanoparticles functionalized with a OX26 type monoclonal antibody for transferrin receptor were developed, targeting the glioblastoma tumor cells, since these cells are known for overexpressing this receptor. The release profile of TMZ from the nanoparticles was studied mimicking physiological conditions, and targeted cellular internalization was also investigated. Two glioblastoma cell lines – U215 and U87 – were used to evaluate the in vitro cytotoxicity of the drug, showing that the prepared nanocarriers enhance the anticancer activity of TMZ. The functionalization with the monoclonal antibody for transferrin receptor proved to be advantageous in enhancing the cellular internalization in glioblastoma cells.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9