Study of Coumarin-Resveratrol Hybrids as Potent Antioxidant Compounds

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Matos, MJ (Author) Other; Mura, F (Author) Other; Vazquez Rodriguez, S (Author) Other; Fernanda Borges (Author) FCUP; Santana, L (Author) Other; Uriarte, E (Author) Other; Olea Azar, C (Author) Other

Journal

Title: Molecules

Vol. 20

Pages: 3290-3308

ISSN: 1420-3049

Publisher: MDPI

Indexing

ISI Web of Knowledge - 36 Citations

Scopus - 40 Citations

Other information

Authenticus ID: P-00G-173

DOI: 10.3390/molecules20023290

Abstract (EN): In the present work we synthesized a selected series of hydroxylated 3-phenylcoumarins 5-8, with the aim of evaluating in detail their antioxidant properties. From an in depth study of the antioxidant capacity data (ORAC-FL, ESR, CV and ROS inhibition) it was concluded that these derivatives are very good antioxidants, with very interesting profiles in all the performed assays. The study of the effect of the number and position of the hydroxyl groups on the antioxidant activity was the principal aim of this study. In particular, 7-hydroxy-3-(3'-hydroxy)phenylcoumarin (8) proved to be the most active and effective antioxidant of the selected series in four of the performed assays (ORAC-FL = 11.8, capacity of scavenging hydroxyl radicals = 54%, Trolox index = 2.33 and AI(30) index = 0.18). However, the presence of two hydroxyl groups on this molecule did not increase greatly the activity profile. Theoretical evaluation of ADME properties of all the derivatives was also carried out. All the compounds can act as potential candidates for preventing or minimizing the free radical overproduction in oxidative-stress related diseases. These preliminary findings encourage us to perform a future structural optimization of this family of compounds.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19