SEPARATION OF ENANTIOMERS OF 1A,2,7,7A-TETRAHYDRO-3-METHOXYNAPHTHA-(2,3B)-OXIRANE BY LIQUID-CHROMATOGRAPHY - LABORATORY-SCALE ELUTION CHROMATOGRAPHY AND MODELING OF SIMULATED MOVING-BED

• Type: Article in International Scientific Journal
• Date: 1995

Authors

Alírio Rodrigues (Author) FEUP; LU, ZP (Author) Other; José Miguel Loureiro (Author) FEUP; PAIS, LS (Author) Other

Journal

Title: Journal of Chromatography A

Vol. 702 No. 1

Pages: 223-231

ISSN: 0021-9673

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 25 Citations

Scopus - 27 Citations

Other information

Authenticus ID: P-001-GWA

DOI: 10.1016/0021-9673(94)01037-f

Abstract (EN): The separation of enantiomers of 1a,2,7,7a-tetrahydro-3-methoxynaphtha-(2,3b)-oxirane (Sandoz epoxide) on cellulose triacetate HPLC columns was investigated on the laboratory scale. The performance of the columns was calculated by HEFT measurements and the slopes of the adsorption equilibrium isotherms and effective diffusivities were calculated from elution chromatographic experiments. Multi-component adsorption equilibrium isotherms were calculated from single isotherms by using the ideal adsorbed solution (IAS) model. Simulation of continuous chromatographic separation of the racemic mixture of Sandoz epoxide in a simulated moving bed was carried out and the effect of mass transfer coefficient on process performance was analysed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9