Antioxidant vitamins and risk of gastric cancer: A case-control study in Portugal

• Type: Article in International Scientific Journal
• Date: 2006

Authors

Lunet N (Author) FMUP; Valbuena, C (Author) Other; Carneiro F (Author) FMUP; Cláudia Lopes (Author) Other; Barros H (Author) FMUP

Journal

Title: Nutrition and Cancer

Vol. 55

Pages: 71-77

ISSN: 0163-5581

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 26 Citations

Other information

Authenticus ID: P-004-QEM

DOI: 10.1207/s15327914nc5501_9

Abstract (EN): We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers. Food intake was assessed with a previously validated semiquantitative food-frequency questionnaire. A commercially available chromatographic immunoassay was used for the detection of immunoglobulin G antibodies. Complete questionnaire information and serum samples were available for 233 cases and 311 controls. Compared with subjects in the lowest tertile of dietary intake, the odds ratios (ORs) for those in the highest were 0.85 (95% confidence interval, CI = 0.45-1.60) for vitamin C, 1.04 (95% CI = 0.60-1.80) for vitamin E, and]. 33 (95% CI = 0.77-2.30)for provitamin A carotenoids after further adjusting for fruit and vegetable consumption. Fruit and vegetables remained an independent protective factor (OR = 0.45; 95% CI = 0.23-0.89) after further adjustment for the intake of antioxidant vitamins. H. pylori status had no significant interaction with dietary items. Factors other than H. pylori infection and intake of vitamin C and provitamin A carotenoids seem to account for the inverse association between fruit and vegetable consumption and gastric cancer.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7