Gastric cancer: adding glycosylation to the equation

• Type: Another Publication in an International Scientific Journal
• Date: 2013

Authors

Pinho, SS (Author) Other; Carvalho, S (Author) Other; Marcos Pinto, R (Author) Other; Magalhaes, A (Author) Other; Oliveira, C (Author) Other; Gu, J (Author) Other; Mario Dinis Ribeiro (Author) FMUP; Carneiro F (Author) FMUP; Seruca, R (Author) FMUP; Celso Reis (Author) ICBAS

Journal

Title: Trends in Molecular Medicine

Vol. 19

Pages: 664-676

ISSN: 1471-4914

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 89 Citations

Scopus - 94 Citations

Other information

Authenticus ID: P-006-JR6

DOI: 10.1016/j.molmed.2013

Abstract (EN): Gastric cancer has a high incidence and mortality, so there is a pressing need to understand the underlying molecular mechanisms in order to discover novel biomarkers. Glycosylation alterations are frequent during gastric carcinogenesis and cancer progression. This review describes the role of glycans from the initial steps of the carcinogenesis process, in which Helicobacter pylori adheres to host mucosa glycans and modulates the glycophenotype, as well as how glycans interfere with epithelial cell adhesion by modulating epithelial cadherin functionality in gastric cancer progression. Other mechanisms regulating gastric cancer malignant behavior are discussed, such as increased sialylation interfering with key signaling pathways and integrin glycosylation leading to an invasive phenotype. Applications of these glycosylation alterations in the clinical management of gastric cancer patients are discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13