Different types of epithelial cadherin alterations play different roles in human carcinogenesis - Commentary

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Sobrinho Simoes, M (Author) FMUP; Oliveira, C (Author) Other

Journal

Title: Advances in Anatomic Pathology

Vol. 9

Pages: 329-337

ISSN: 1072-4109

Publisher: Wolters Kluwer Health

Indexing

ISI Web of Knowledge - 6 Citations

Scopus - 7 Citations

Other information

Authenticus ID: P-000-MET

DOI: 10.1097/00125480-200211000-00001

Abstract (EN): Epithelial cadherin (E-cadherin) gene and protein alterations are implicated in the existence of two clearly distinct types of tumors in the stomach (isolated cell and glandular carcinomas), breast (lobular and ductal carcinomas), and thyroid (papillary and follicular carcinomas), as well as in the occurrence of poorly differentiated foci in colorectal and prostate adenocarcinomas. A thorough correlation between clinicopathologic features and molecular data, and the study of early lesions from familial cases provide clues for the understanding of the role played by E-cadherin in these settings.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9