MICROSATELLITE INSTABILITY IS ASSOCIATED WITH TUMORS THAT CHARACTERIZE THE HEREDITARY NONPOLYPOSIS COLORECTAL-CARCINOMA SYNDROME

• Type: Another Publication in an International Scientific Journal
• Date: 1993

Authors

PELTOMAKI, P (Author) Other; LOTHE, RA (Author) Other; AALTONEN, LA (Author) Other; PYLKKANEN, L (Author) Other; NYSTROMLAHTI, M (Author) Other; Seruca, R (Author) Other; David L (Author) FMUP; HOLM, R (Author) Other; RYBERG, D (Author) Other; HAUGEN, A (Author) Other; BROGGER, A (Author) Other; BORRESEN, AL (Author) Other; DELACHAPELLE, A (Author) Other

Journal

Title: Cancer Research

Vol. 53

Pages: 5853-5855

ISSN: 0008-5472

Publisher: American Association for Cancer Research

Indexing

ISI Web of Knowledge - 592 Citations

Scopus - 589 Citations

Other information

Authenticus ID: P-001-MBA

Abstract (EN): Microsatellite instability implying multiple replication errors (RER+ phenotype) characterizes a proportion of colorectal carcinomas, particularly those from patients with the hereditary non-polyposis colorectal carcinoma syndrome. We studied the incidence of microsatellite instability in more than 500 sporadic tumors representing 6 different types of cancer. Apart from colorectal carcinoma [see the paper by Lothe et al. (Cancer Res., 53: 5849-5852, 1993)] the RER+ phenotype was found in 18% (6 of 33) of gastric carcinomas and 22% (4 of 18) of endometrial carcinomas. In contrast, no evidence of this abnormality was detected in cancers of the lung (N = 85), breast (N = 84), and testis (N = 86). Importantly, the first three cancers, as opposed to the latter three, are characteristic of the hereditary non-polyposis colorectal carcinoma syndrome. These findings suggest that the cancers belonging to the hereditary non-polyposis colorectal carcinoma tumor spectrum may have essential pathogenetic steps in common, including a tendency to multiple replication errors.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3