FAMILIAL GASTRIC POLYPOSIS REVISITED - AUTOSOMAL DOMINANT INHERITANCE CONFIRMED

• Type: Article in International Scientific Journal
• Date: 1991

Authors

Seruca, R (Author) Other; Carneiro F (Author) FMUP; CASTEDO, S (Author) FMUP; David L (Author) FMUP; LOPES, C (Author) Other; Sobrinho Simoes, M (Author) FMUP

Journal

Title: Cancer Genetics and Cytogenetics

Vol. 53

Pages: 97-100

ISSN: 0165-4608

Publisher: Elsevier B.V.

Indexing

ISI Web of Knowledge - 19 Citations

Scopus - 30 Citations

Other information

Authenticus ID: P-001-QRS

DOI: 10.1016/0165-4608(91)90119-f

Abstract (EN): We update and review a large pedigree originally described by Santos and Magalhaes with familial gastric polyposis and a high incidence of gastric cancer. The present observation of male-to-male transmission of the disease clearly demonstrates the autosomal dominant pattern of inheritance. The histologic review of the polyps present in several members of the family allowed the diagnosis of hyperplastic polyposis. Eight members of the family (two with concomitant gastric pathology) have severe cutaneous psoriasis. This finding may represent the existence of two different disorders segregating in the family or, alternatively, pleiotropic manifestations of the same gene.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4