Lessons from black pepper: piperine and derivatives thereof

• Type: Another Publication in an International Scientific Journal
• Date: 2016

Authors

Chavarria, D (Author) Other; Silva, T (Author) Other; Magalhaes e Silva, DME (Author) Other; Fernando Remiao (Author) FFUP; Fernanda Borges (Author) FCUP

Journal

Title: Expert Opinion on Therapeutic Patents

Vol. 26

Pages: 245-264

ISSN: 1354-3776

Publisher: Taylor & Francis

Indexing

ISI Web of Knowledge - 28 Citations

Scopus - 33 Citations

Other information

Authenticus ID: P-00K-4ZX

DOI: 10.1517/13543776.2016.1118057

Abstract (EN): Introduction: Piperine is a simple and pungent alkaloid found in the seeds of black pepper (Piper nigrum). Following its isolation and full characterization, the biological properties of piperine have been extensively studied, and piperine-like derivatives have shown an interesting range of pharmacological activities. In this context, significant advances have been made in the discovery of new chemical entities based on the piperine scaffold endowed with therapeutic potential. Areas covered: The aim of this review is to provide a thorough inquiry on the therapeutic potential of piperine and related derivatives. It provides an overview of recent developments in patented processes and applications thereof between 2000 and 2015. Expert opinion: Cumulative evidence shows that piperine is currently paving its way to become a privileged scaffold for the development of bioactive compounds with therapeutic application in multiple human diseases. In particular, piperine derivatives were shown to modulate the activity of several targets related to neurological disorders, including epilepsy, Parkinson's disease, depression and pain related disorders. Moreover, the efflux pump inhibitory ability of piperine and its analogues tackles important drug resistance mechanisms and may improve the clinical efficacy of antibiotic and anticancer drugs. Although the use of piperine as a scaffold for bioactive compounds is still in its early stages, the continuous exploration of this structure may lead to remarkable advances in drug discovery programs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20