Measurement of glomerulus diameter and Bowman's space width of renal albino rats

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Taras Kotyk (Author) Other; Nilanjan Dey (Author) Other; Amira S. Ashour (Author) Other; Dana Balas-Timar (Author) Other; Sayan Chakraborty (Author) Other; Ahmed S. Ashour (Author) Other; João Manuel R. S. Tavares (Author) FEUP

Journal

Title: Computer Methods and Programs in Biomedicine

Vol. 126

Pages: 143-153

ISSN: 0169-2607

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 20 Citations

ISI Web of Science

Scopus - 0 Citations

INSPEC

Scientific classification

CORDIS: Technological sciences

FOS: Medical and Health sciences

Other information

Authenticus ID: P-00K-7NC

DOI: 10.1016/j.cmpb.2015.10.023

Abstract (EN): Glomerulus diameter and Bowman’s space width in renal microscopic images indicate various diseases. Therefore, the detection of the renal corpuscle and related objects is a key step in histopathological evaluation of renal microscopic images. However, the task of automatic glomeruli detection is challenging due to their wide intensity variation, besides the inconsistency in terms of shape and size of the glomeruli in the renal corpuscle. Here, a novel solution is proposed which includes the Particles Analyzer technique based on median filter for morphological image processing to detect the renal corpuscle objects. Afterwards, the glomerulus diameter and Bowman’s space width are measured. The solution was tested with a dataset of 21 rats’ renal corpuscle images acquired using light microscope. The experimental results proved that the proposed solution can detect the renal corpuscle and its objects efficiently. As well as, the proposed solution has the ability to manage any input images assuring its robustness to the deformations of the glomeruli even with the glomerular hypertrophy cases. Also, the results reported significant difference between the control and affected (due to ingested additional daily dose (14.6mg) of fructose) groups in terms of glomerulus diameter (97.40 ± 19.02m and 177.03 ± 54.48m, respectively).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 11