UNUSUAL GROWTH-CHARACTERISTICS OF HUMAN-MELANOMA XENOGRAFTS IN THE NUDE-MOUSE - A MODEL FOR DESMOPLASIA, DORMANCY AND PROGRESSION

• Type: Article in International Scientific Journal
• Date: 1992

Authors

Fátima Gärtner (Author) Other; FEARNS, C (Author) Other; WILSON, EL (Author) Other; CAMPBELL, JAH (Author) Other; DOWDLE, EB (Author) Other

Journal

Title: British Journal of Cancer

Vol. 65

Pages: 487-490

ISSN: 0007-0920

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 27 Citations

Scopus - 26 Citations

Other information

Authenticus ID: P-008-P5S

DOI: 10.1038/bjc.1992.101

Abstract (EN): When human melanoma cells are injected into nude mice they usually give rise to tumours that grow progressively and do not elicit a prominent host response. We have recently developed a melanoma cell line, UCT-Mel 7, that did not show these characteristics. In the first place UCT-Mel 7 showed a consistently unusual, phasic growth pattern. After a short initial period of limited growth (phase 1), the tumour ceased growing and remained static for 2-3 months (phase 2). The tumour then regressed (phase 3) to enter a second period of quiescence (phase 4) which was eventually broken by the emergence of a rapidly growing lethal tumour (phase 5). Of particular interest was the fact that the rate at which the tumours grew correlated closely with their collagen content. During the prolonged, phase 2 plateau, the tumours were intensely desmoplastic; rapidly growing phase 5 tumours, that had escaped from dormancy, contained very little collagen and virtually no reticulin. This cell line helps to fill an important need for an experimental system for the study of desmoplasia, dormancy and progression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 4