E-cadherin, beta-catenin, mivasion and lymph node metastases in canine malignant mammary tumours

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Augusto Matos (Author) ICBAS; Célia Lopes (Author) ICBAS; Rodrigues Faustino, AMR (Author) Other; carvalheira, j (Author) ICBAS; Rutteman, GR (Author) Other; Fátima Gärtner (Author) ICBAS

Journal

Title: APMIS: acta pathologica, microbiologica, et immunologica Scandinavica

Vol. 115

Pages: 327-334

ISSN: 0903-4641

Publisher: John Wiley & Sons

Indexing

ISI Web of Knowledge - 20 Citations

Scopus - 25 Citations

Other information

Authenticus ID: P-004-APZ

DOI: 10.1111/j.1600-0463.2007.apm_544.x

Abstract (EN): Recent studies of canine malignant mammary tumours suggest that reduction of E-cadherin and/or P-catenin correlates with invasive behaviour and lymph node metastasis. The aims of this study were to examine the interrelationships between the expression of E-cadherin and beta-catenin, and the relationship between the expression of E-cadherin and/or beta-catenin and the mode of growth and metastatic capacity of canine malignant mammary tumours. 90 spontaneous malignant turnours and local and regional lymph nodes were studied. A significant relationship was evidenced between membranous expression of E-cadherin and beta-catenin (p=0.0027), but not between E-cadherin and cytoplasmic beta-catenin. Only E-cadherin as a separate factor was significantly related to tumour invasion (p=0.0072) and lymph node metastasis (p=0.0001). Neither membranous nor cytoplasmic beta-catenin expression was significantly related to either of these phenomena.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8