Computer-Aided Drug Design Methodologies Toward the Design of Anti-Hepatitis C Agents

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Alejandro Speck Planche (Author) Other; Natalia N D S Cordeiro (Author) FCUP

Journal

Title: Current Topics in Medicinal Chemistry

Vol. 12

Pages: 802-813

ISSN: 1568-0266

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 24 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-BGV

DOI: 10.2174/156802612800166783

Abstract (EN): Hepatitis C constitutes an infectious disease that causes severe damages to the liver, and is caused by hepatitis C virus. There is no vaccine against this type of disease and the number of people infected continues to grow worldwide. The anti-viral therapy which is currently used is a mixture of interferon alpha-2a with ribavirin, but approximately half of the patients do not respond to therapy. Therefore, it is necessary to search for new compounds with anti-hepatitis C activity. Computer-aided drug design methodologies have been vital in the discovery of candidates to drugs. This review is dedicated to the role of computer-aided drug design methodologies for the development of new anti-hepatitis C agents. In addition, we introduce a QSAR model based on substructural approaches in order to model the anti-hepatitis C activity in vivo.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12