Discovery of Anti-Alzheimer Agents: Current Ligand-Based Approaches toward the Design of Acetylcholinesterase Inhibitors

• Type: Another Publication in an International Scientific Journal
• Date: 2012

Authors

Speck Planche, A (Author) Other; Luan, F (Author) Other; Cordeiro, MNDS (Author) FCUP

Journal

Title: Mini-Reviews in Medicinal Chemistry

Vol. 12

Pages: 583-591

ISSN: 1389-5575

Publisher: Bentham Science

Indexing

ISI Web of Knowledge - 21 Citations

Scopus - 21 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-002-9B3

Abstract (EN): Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive dementia and loss of cognitive abilities. Until now, AD remains incurable. The principal biological target for AD therapy is acetylcholinesterase (AChE). Thus, the search for new drug candidates like AChE inhibitors constitutes an essential part for the discovery of more potent anti-AD agents. In general terms, rational drug design methodologies have played a decisive role. The present work is focused on the current state of the Ligand-Based Drug Design (LBDD) methods which have been applied to the elucidation of new molecular entities with high anti-AChE activity. Also, as a contribution to this field, we suggest a promising fragment-based approach for the search and prediction of new AChE inhibitors and for the fast and efficient extraction of substructural alerts which are responsible for the anti-AChE activity.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9