Prognostic biomarkers in thyroid cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2014

Authors

Paula Soares (Author) FMUP; Ricardo Celestino (Author) Other; Miguel Melo (Author) Other; Elsa Fonseca (Author) Other; Manuel Sobrinho Simoes (Author) Other

Journal

Title: Virchows Archiv

Vol. 464

Pages: 333-346

ISSN: 0945-6317

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 40 Citations

Scopus - 44 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-009-BP2

DOI: 10.1007/s00428-013-1521-2

Abstract (EN): Thyroid carcinomas represent a challenging problem from the prognostic standpoint. Despite an overall good prognosis of the most frequent endocrine malignancy, 10-15 % of papillary thyroid carcinomas (PTCs) turn refractory to radioactive iodine therapy. The increased incidence of thyroid cancer has led to the search for solid prognostic biomarkers that predict the behaviour of these tumours. Clinical and histopathological prognostic factors remain the only safe elements to be used for diagnosis and prognosis of patients with thyroid tumours. Despite the huge amount of genetic information of thyroid tumours, very few new markers revealed diagnostic or prognostic value per se. BRAF mutation can have some value if associated to other clinico-pathological parameters, or in the particular setting of iodine refractory tumours. Others can prove interesting in the future as predictive biomarkers of therapeutic response, but more studies are needed to confirm these potential biomarkers.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14