Flavonoids Inhibit COX-1 and COX-2 Enzymes and Cytokine/Chemokine Production in Human Whole Blood

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Daniela Ribeiro (Author) Other; Marisa Freitas (Author) Other; Sara M Tome (Author) Other; Artur M S Silva (Author) Other; Stefan Laufer (Author) Other; Jose L F C Lima (Author) Other; Eduarda Fernandes (Author) FFUP

Journal

Title: Inflammation

Vol. 38

Pages: 858-870

ISSN: 0360-3997

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 26 Citations

Scopus - 51 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-00G-271

DOI: 10.1007/s10753-014-9995-x

Abstract (EN): Cyclooxygenase 2 (COX-2) and the production of cytokines/chemokines are important targets for the modulation of the inflammatory response. Although a large variety of inhibitors of these pathways have been commercialized, some of those inhibitors present severe side effects, governing the search for new molecules, as alternative anti-inflammatory agents. This study was undertaken to study an hitherto not evaluated group of flavonoids, concerning its capacity to inhibit COX-1 and COX-2 enzymes, as well as to inhibit the production of the cytokines and a chemokine, in a complex matrix involved in the systemic inflammatory process, the blood, aiming the establishment of a structure-activity relationship. The results obtained reveal promising flavonoids for the modulation of the inflammatory process, namely the ones presenting a catechol group in B ring, as some flavonoids were able to simultaneously inhibit the production of inflammatory prostaglandin E-2 and pro-inflammatory cytokines.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13