Lipid-based colloidal carriers for peptide and protein delivery - liposomes versus lipid nanoparticles

• Type: Another Publication in an International Scientific Journal
• Date: 2007

Authors

Susana Martins (Author) Other; Bruno Sarmento (Author) Other; Domingos C Ferreira (Author) FFUP; Eliana B Souto (Author) Other

Journal

Title: International Journal of Nanomedicine

Vol. 2

Pages: 595-607

ISSN: 1176-9114

Publisher: Dove Medical Press

Indexing

ISI Web of Knowledge - 237 Citations

Scopus - 313 Citations

Scientific classification

FOS: Engineering and technology > Nano-technology

Other information

Authenticus ID: P-004-DHD

Abstract (EN): This paper highlights the importance of lipid-based colloidal carriers and their pharmaceutical implications in the delivery of peptides and proteins for oral and parenteral administration. There are several examples of biomacromolecules used nowadays in the therapeutics, which are promising candidates to be delivered by means of liposomes and lipid nanoparticles, such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). Several production procedures can be applied to achieve a high association efficiency between the bioactives and the carrier, depending on the physicochemical properties of both, as well as on the production procedure applied. Generally, this can lead to improved bioavailability, or in case of oral administration a more consistent temporal profile of absorption from the gastrointestinal tract. Advantages and drawbacks of such colloidal carriers are also pointed out. This article describes strategies used for formulation of peptides and proteins, methods used for assessment of association efficiency and practical considerations regarding the toxicological concerns.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 13