Regenerative Medicine

Code:

OPT132

Acronym:

MR

Keywords
Classification	Keyword
OFICIAL	Medicine

Instance: 2018/2019 - 2S (of 11-02-2019 to 12-07-2019)

Active?	Yes
Responsible unit:	Departamento de Biomedicina
Course/CS Responsible:	Integrated Master in Medicine

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIMED	23	Mestrado Integrado em Medicina- Plano oficial 2013 (Reforma Curricular)	4	-	3	21	81
			5

Teaching language

Suitable for English-speaking students

Objectives

The course aims to introduce students to the new and growing field of Regenerative Medicine, a continuously expanding field of scientific and clinical applications addressing the molecular and cellular basis of cell differentiation and tissue organization. The course aims to expand the histology knowledge obtained in the several courses of Morphophysiology during the 1^st and 2^nd years of the Medical School, putting them in a functional perspective that will serve as a foundation for understanding the scientific advances in tissue regeneration that are of current clinical application.

The unit will have four main objectives:

1. To provide students with a comprehensive overview of the mechanisms of normal control of cell proliferation and differentiation as well as the mechanisms governing normal tissue healing,
2. To provide students with a thorough updated knowledge on the biology of stem cells and other pluripotent cell lines,
3. To introduce students to the varied technologies and materials that make up the current field of tissue engineering,
4. To introduce students to the latest developments in clinical application of methodologies for cell reprogramming and tissue engineering.

Learning outcomes and competences

Overall, the knowledge gained in the course will serve not only to gain an in-depth contact with an area of growing importance in medicine, but at the same time it will equip the students with a critical view of the continuous developments that will occur in this area of medicine.

Working method

Presencial

Program

Interim program.

1. IIntroduction. Biological bases of regenerative medicine.
2. Nanobiomaterials in regenerative medicine I
3. Nanobiomaterials in regenerative medicine II
4. Stem cells: cell types and biological regulation.
5. Stem cells in central nervous system repair
6. Endogenous mechanisms of nervous system repair
7. Clinical application of regenerative medicine techniques: Orthpaedics
8. Clinical application of regenerative medicine techniques: Urology
9. AClinical application of regenerative medicine techniques: Plastic surgery
10. Clinical application of regenerative medicine techniques: Gastroenterology
11. Clinical application of regenerative medicine techniques: Liver
12. Tutoria: preparação dos projetos
13. Tutoria: preparação dos projetos
14. Apresentação dos projetos

Mandatory literature

Atala A, Lanza R, Thomson JA, Nerem RM (editores) ; Principles of Regenerative Medicine (2ª Ed)
Carlson B. ; Principles of Regenerative Biology (1ª Ed)
Lanza R; Essentials of Stem Cell Biology (2ª Ed)
Meyer U, Meyer T, Handshel J, Wiesmann HP (editores) ; FFundamentals of Tissue Engineering and Regenerative Medicine (1ª Ed)undamentals of Tissue Engineering and Regenerative Medicine (1ª Ed)

Comments from the literature

In each lecture, aditional references may be recommended (scientific reports, reviews, comments..).

Teaching methods and learning activities

Lecures, group work.
Presentations of a relevant subject in the context of regenerative medicine.

Evaluation Type

Distributed evaluation without final exam

Assessment Components

Designation	Weight (%)
Apresentação/discussão de um trabalho científico	50,00
Trabalho escrito	50,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Apresentação/discussão de um trabalho científico	3,00
Estudo autónomo	15,00
Frequência das aulas	65,00
Trabalho escrito	20,00
Total:	103,00

Eligibility for exams

Attending the required number of lectures according to the paedagogical regulation of FMUP. Minimum mark of 9,5.

Calculation formula of final grade

50% public presentation; 50% written project