Transferrin surface-modified PLGA nanoparticles-mediated delivery of a proteasome inhibitor to human pancreatic cancer cells

• Type: Article in International Scientific Journal
• Date: 2015

Authors

Manuela F. Frasco (Author) FEUP; Gabriela M. Almeida (Author) Other; Filipe Santos Silva (Author) Other; Maria do Carmo Pereira (Author) FEUP; Manuel A. N. Coelho (Author) FEUP

Journal

Title: Journal of Biomedical Materials Research - Part A

Vol. 103 No. 4

Pages: 1476-1484

ISSN: 1549-3296

Publisher: Wiley-Blackwell

Indexing

ISI Web of Knowledge

Scopus - 0 Citations

Associated Projects

BIONANO - Distibuição de biomoleculas através de nanopartículas inorganica/organicas

Other information

Authenticus ID: P-009-W7T

DOI: 10.1002/jbm.a.35286

Abstract (EN): The aim of this study was to develop a drug delivery system based on poly(lactic-co-glycolic acid) (PLGA) nanoparticles for an efficient and targeted action of the proteasome inhibitor bortezomib against pancreatic cancer cells. The PLGA nanoparticles were formulated with a poloxamer, and further surface-modified with transferrin for tumor targeting. The nanoparticles were characterized as polymer carriers of bortezomib, and the cellular uptake and growth inhibitory effects were evaluated in pancreatic cells. Cellular internalization of nanoparticles was observed in normal and cancer cells, but with higher uptake by cancer cells. The sustained release of the loaded bortezomib from PLGA nanoparticles showed cytotoxic effects against pancreatic normal and cancer cells. Noteworthy differential cytotoxicity was attained by transferrin surface-modified PLGA nanoparticles since significant cell growth inhibition by delivered bortezomib was only observed in cancer cells. These findings demonstrate that the ligand transferrin enhanced the targeted delivery of bortezomib-loaded PLGA nanoparticles to pancreatic cancer cells. These in vitro results highlight the transferrin surface-modified PLGA nanoparticles as a promising system for targeted delivery of anticancer drugs. © 2014 Wiley Periodicals, Inc.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9