Lipid Nanocarriers for Hyperproliferative Skin Diseases

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Souto, EB (Author) Other; de Souza, ALR (Author) Other; dos Santos, FK (Author) Other; Sanchez Lopez, E (Author) Other; Cano, A (Author) Other; Zielinska, A (Author) Other; Staszewski, R (Author) Other; Karczewski, J (Author) Other; Gremiao, MPD (Author) Other; Chorilli, M (Author) Other

Journal

Title: Cancers

Vol. 39

Final page: 5619

ISSN: 2072-6694

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00V-P11

DOI: 10.3390/cancers13225619

Abstract (EN): Simple SummaryDifferent drugs, including antiproliferative and corticosteroids in general, are recommended for the treatment of hyperproliferative skin diseases (HSD). The effectiveness of many of these drugs is limited due to their low solubility in water and low penetration in the skin. The loading of these drugs in lipid nanocarriers, such as lipid nanoparticles and liposomes, has been considered as a successful solution to improve the drug bioavailability through the skin, to control their release kinetics and thus reduce the risk of potential side effects. In this work, we discuss the use of lipid nanocarriers loading drugs against HSD.Hyperproliferative skin diseases (HSD) are a group of diseases that include cancers, pre-cancerous lesions and diseases of unknown etiology that present different skin manifestations in terms of the degree and distribution of the injuries. Anti-proliferative agents used to treat these diseases are so diverse, including 5-aminolevulinic acid, 5-fluorouracil, imiquimod, methotrexate, paclitaxel, podophyllotoxin, realgar, and corticosteroids in general. These drugs usually have low aqueous solubility, which consequently decreases skin permeation. Thus, their incorporation in lipid nanocarriers has been proposed with the main objective to increase the effectiveness of topical treatment and reduce side effects. This manuscript aims to describe the advantages of using lipid nanoparticles and liposomes that can be used to load diversity of chemically different drugs for the treatment of HSD.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 16