Impaired Fasting Glucose and Chronic Kidney Disease, Albuminuria, or Worsening Kidney Function: A Secondary Analysis of SPRINT

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Vieira, MB (Author) Other; Neves, JS (Author) FMUP; Leitao, L (Author) Other; Baptista, RB (Author) Other; Magrico, R (Author) Other; Dias, CV (Author) Other; Oliveira, A (Author) Other; Carvalho, Davide (Author) FMUP; Mc Causland, FR (Author) Other

Journal

Title: Journal of Clinical Endocrinology and Metabolism

Vol. 104

Pages: 4024-4032

ISSN: 0021-972X

Publisher: Endocrine Society

Indexing

ISI Web of Knowledge - 12 Citations

Scopus - 14 Citations

Other information

Authenticus ID: P-00R-0KF

DOI: 10.1210/jc.2019-00073

Abstract (EN): Purpose: Diabetes mellitus is a risk factor for the development and progression of chronic kidney disease (CKD). However, the association of prediabetes with adverse kidney outcomes is uncertain. Methods: We performed a secondary analysis of the Systolic Blood Pressure Intervention Trial (SPRINT), including 9361 participants without diabetes at baseline. We categorized participants according to fasting glucose level as having impaired fasting glucose [>= 100 mg/dL (>= 5.6 mmol/L)] or normoglycemia [<100 mg/dL (<5.6 mmol/L)]. Unadjusted and adjusted proportional hazards models were fitted to estimate the association of impaired fasting glucose (vs normoglycemia) with a composite outcome of worsening kidney function [>= 30% decrease in estimated glomerular filtration rate (eGFR) to <60 mUmin/1.73 m(2) in participants without baseline CKD; >= 50% decrease in eGFR or need for long-term dialysis/kidney transplantation in participants with CKD] or incident albuminuria (doubling of urinary albumin/creatinine ratio from <10 mg/g to >10 mg/g). These outcomes were also evaluated separately and according to CKD status at baseline. Results: Participants' mean age was 67.9 +/- 9.4 years, 35.5% were female, and 31.4% were black. The median follow-up was 3.3 years, and 41.8% had impaired fasting glucose. Impaired fasting glucose was not associated with higher rates of the composite outcome [hazard ratio (HR): 0.97; 95% CI: 0.8 to 1.16], worsening kidney function (HR: 1.02; 95% CI: 0.75 to 1.37), or albuminuria (HR: 0.98; 95% CI: 0.78 to 1.23). Similarly, there was no association of impaired fasting glucose with outcomes according to baseline CKD status. Conclusions: Impaired fasting glucose at baseline was not associated with the development of worsening kidney function or albuminuria in participants of SPRINT.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 9