Swellable polymeric particles for the local delivery of budesonide in oral mucositis

• Type: Article in International Scientific Journal
• Date: 2019

Authors

Campos, JC (Author) Other; Ferreira, DC (Author) FFUP; Lima, S (Author) Other; Salette Reis (Author) FFUP; Paulo Costa (Author) FFUP

Journal

Title: International Journal of Pharmaceutics

Vol. 566

Pages: 126-140

ISSN: 0378-5173

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 3 Citations

Scopus - 4 Citations

Other information

Authenticus ID: P-00Q-HH0

DOI: 10.1016/j.ijpharm.2019.05.057

Abstract (EN): Topical drug delivery in the oral mucosa has its set of challenges due to the unique anatomical and physiological features of the oral cavity. As such, the outcomes of local pharmacological treatments in oral disorders can fail due to unsuccessfully drug delivery. Oral mucositis, a severe inflammatory and ulcerative side effect of oncological treatments, is one of such diseases. Although the damaged tissue is within reach, no approved topical drug treatment is available. Several strategies based on its physiopathology have been implemented and clinically used. Even so, results tend to lack or be insufficient to improve patient's quality of life. The use of corticosteroids has been employed in such strategies due to their strong anti-inflammatory action. Typically, these are administrated in simple liquid formulations, where the drug is dispersed or solubilized, lacking the ability to maintain local concentration. In this work, we propose the development of a biocompatible delivery system with boosted abilities of retention and control release of budesonide, a corticosteroid with an elevated ratio of topical anti-inflammatory to systemic action. Through spray-drying, polymeric particles of Chitosan and Eudragit (R) E PO were produced and characterized for the vectorization of this drug.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 15