Intercellular Transfer of Cancer Drug Resistance Traits by Extracellular Vesicles

• Type: Another Publication in an International Scientific Journal
• Date: 2015

Authors

Sousa, D (Author) Other; Lima, RT (Author) Other; Helena Vasconcelos, MH (Author) FFUP

Journal

Title: Trends in Molecular Medicine

Vol. 21

Pages: 595-608

ISSN: 1471-4914

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 94 Citations

Scopus - 100 Citations

Other information

Authenticus ID: P-00G-P9E

DOI: 10.1016/j.molmed.2015.08.002

Abstract (EN): Extracellular vesicles (EVs) are nanosized particles (100-1000 nm) enclosed by a phospholipid bilayer that have been described as important mediators of intercellular communication. The role of EVs in oncobiology has been extensively studied, including their contribution to the horizontal transfer of drug resistance from drug-resistant to drug-sensitive cancer cells. This review focuses on the EVs cargo responsible for this intercellular transfer of drug resistance; namely, drug-efflux pumps, miRNAs, long noncoding RNAs (IncRNAs), and other mediators. Additionally, the known molecular mechanisms and features of this transfer are discussed. This is an emerging area of research and we highlight topics that need to be further studied to fully understand and counteract the intercellular transfer of drug resistance mediated by EVs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14