Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden

• Type: Article in International Scientific Journal
• Date: 2012

Authors

Bettencourt, N (Author) Other; Toschke, AM (Author) Other; Leite, D (Author) Other; Rocha, J (Author) Other; Carvalho, M (Author) Other; Sampaio, F (Author) Other; Xara, S (Author) Other; Leite-Moreira AF (Author) FMUP; Nagel, E (Author) Other; Gama, V (Author) Other

Journal

Title: International Journal of Cardiology

Vol. 158

Pages: 26-32

ISSN: 0167-5273

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 132 Citations

Scopus - 133 Citations

Other information

Authenticus ID: P-002-8VE

DOI: 10.1016/j.ijcard.2010.12.085

Abstract (EN): Introduction: Epicardial adipose tissue (EAT) may play an active role in the development of coronary artery disease (CAD). The aim of this work was to study the relations between EAT, abdominal visceral fat (AVF), and coronary atherosclerotic burden as assessed by multislice computed tomography (MSCT). Population and methods: Two hundred fifteen patients without known CAD referred to 64-SCT during a 6-months period were included. All patients underwent a standardized protocol including quantification of AVF, EAT, coronary artery calcification (CAC), and coronary angiography by MSCT. Results: Two hundred fifteen patients, with mean age of 58 +/- 11 years, in which 61% were males, with mean body mass index (BMI) of 28 +/- 4 kg/m(2) were included. EAT volume was directly associated with male sex, age, BMI, abdominal circumference, AVF, number of coronary segments with atherosclerotic plaques (p<0.01 for all), number of segments with significant stenoses, and presence of metabolic syndrome components (p<0.05). CAC increased by 14.7% per additional 10 ml of EAT volume. Adjusting for age, gender, and AVF changed this increase to 7.5%. After adjusting for all considered confounders, there was still an independent association, with a CAC increase of 3.7% per additional 10 ml of EAT. A significant interaction was found between EAT volume and gender and between EAT volume and obesity: an increase of EAT was associated with an increase of additional 8% of CAC in men, and additional increase of 5% in non-obese individuals (p<0.001 for both). Conclusion: EAT volume positively relates to coronary atherosclerotic burden, as assessed by CAC; this correlation was shown to be independent of AVF.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7