P53 MUTATIONS IN GASTRIC CARCINOMAS

• Type: Another Publication in an International Scientific Journal
• Date: 1992

Authors

Seruca, R (Author) Other; David L (Author) FMUP; HOLM, R (Author) Other; NESLAND, JM (Author) Other; FANGAN, BM (Author) Other; CASTEDO, S (Author) FMUP; Sobrinho Simoes, M (Author) FMUP; BORRESEN, AL (Author) Other

Journal

Title: British Journal of Cancer

Vol. 65

Pages: 708-710

ISSN: 0007-0920

Publisher: Springer Nature

Indexing

ISI Web of Knowledge - 59 Citations

Scopus - 50 Citations

Other information

Authenticus ID: P-001-PKT

DOI: 10.1038/bjc.1992.149

Abstract (EN): We carried out an immunohistochemical study and DNA analysis of 30 gastric carcinomas to evaluate p53 overexpression and allelic loss at 17p. The immunohistochemical study demonstrated immunoreactivity for p53 protein in four cases. Allelic loss for the pYNZ22.1 marker was detected in nine cases. In total, ten cases showed immunoreactivity for p53 protein, allelic loss, or both. The study of nine of these cases by constant denaturant gel electrophoresis revealed p53 mutations in three cases. We conclude that the prevalence of mutations of p53 in our series is similar to what has recently been observed in other cases of gastric cancer, but lower than in colon carcinomas.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3