Shear viscosity and nonlinear behavior of whole blood under large amplitude oscillatory shear

• Type: Article in International Scientific Journal
• Date: 2013

Authors

P. C. Sousa (Author) FEUP; J. Carneiro (Author) FEUP; R. Vaz (Author) FMUP; A. Cerejo (Author) FMUP; Fernando Tavares de Pinho (Author) FEUP; Manuel Alves (Author) FEUP; Mónica Oliveira (Author) FEUP

Journal

Title: Biorheology

Vol. 50

Pages: 269-282

ISSN: 0006-355X

Publisher: IOS PRESS

Indexing

ISI Web of Knowledge - 54 Citations

ISI Web of Science

Scopus - 55 Citations

INSPEC

Scientific classification

FOS: Engineering and technology

Associated Projects

ANEURYSM - ANEURYSM - Estudo Hemodinâmico em Aneurismas Cerebrais

CSD-Chip - CSD-Chip - Desenvolvimento de um biochip para a separação e deformação de células sanguíneas

RheoChip - Design de um "reómetro-num-chip" para o desenvolvimento de fluidos análogos ao sangue

Other information

Authenticus ID: P-008-QRE

DOI: 10.3233/BIR-130643

Abstract (EN): We investigated experimentally the rheological behavior of whole human blood subjected to large amplitude oscillatory shear under strain control to assess its nonlinear viscoelastic response. In these rheological tests, the shear stress response presented higher harmonic contributions, revealing the nonlinear behavior of human blood that is associated with changes in its internal microstructure. For the rheological conditions investigated, intra-cycle strain-stiffening and intra-cycle shear-thinning behavior of the human blood samples were observed and quantified based on the Lissajous¿Bowditch plots. The results demonstrated that the dissipative nature of whole blood is more intense than its elastic component. We also assessed the effect of adding EDTA anticoagulant on the shear viscosity of whole blood subjected to steady shear flow. We found that the use of anticoagulant in appropriate concentrations did not influence the shear viscosity and that blood samples without anticoagulant preserved their rheological characteristics approximately for up to 8 minutes before coagulation became significant.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 14