Hippocampal mossy fibre boutons as dynamical synapses

• Type: Article in International Conference Proceedings Book
• Date: 2004

Authors

Aguiar, P (Author) Other; Willshaw, D (Author) Other

Conference proceedings International

Title: COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004

Pages: 699-703

12th Annual Computational Neuroscience Meeting (CNS 03)

Alicante, SPAIN, JUL 05-09, 2003

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Scopus - 1 Citation

Other information

Authenticus ID: P-007-E25

DOI: 10.1016/j.neucom.2004.01.116

Abstract (EN): In this work the consequences on the activity of CA3 pyramidal neurons of the dynamic properties (facilitation and depression) associated with hippocampal mossy fibre boutons are explored; namely, a study is carried on the dependence of the pyramidal cell activity with the input stimulus frequency to the mossy fibre boutons as well as the influence of the single vesicle post-synaptic response magnitude on this dependence. We calculate tuning curves for the mossy fibre boutons excitatory post-synaptic potentials as a function of pre-synaptic frequency and we show how this property, together with channels that contribute to spike frequency adaptation, makes the activity of CA3 pyramidal neurons strongly dependent on the temporal patterns of mossy fibres pre-synaptic signals.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 5