Oral insulin delivery by means of solid lipid nanoparticles

• Type: Article in International Scientific Journal
• Date: 2007

Authors

Bruno Sarmento (Author) Other; Susana Martins (Author) Other; Domingos Ferreira (Author) FFUP; Eliana B Souto (Author) Other

Journal

Title: International Journal of Nanomedicine

Vol. 2

Pages: 743-749

ISSN: 1176-9114

Publisher: Dove Medical Press

Indexing

ISI Web of Knowledge - 178 Citations

Scopus - 235 Citations

Scientific classification

FOS: Engineering and technology > Nano-technology

Other information

Authenticus ID: P-004-DHE

Abstract (EN): The aim of this work was to produce and characterize cetyl palmitate-based solid lipid nanoparticles (SLN) containing insulin, and to evaluate the potential of these colloidal carriers for oral administration. SLN were prepared by a modified solvent emulsification-evaporation method based on a w/o/w double emulsion. The particle size, zeta potential and association efficiency of unloaded and insulin-loaded SLN were determined and were found to be around 350 nm, negatively charged and the insulin association efficiency was over 43%. After oral administration of insulin-loaded SLN to diabetic rats, a considerable hypoglycemic effect was observed during 24 hours. These results demonstrated that SLN promote the oral absorption of insulin.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 7