The role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Santos, M (Autor) Outra; Carvalho, S (Autor) Outra; Lima, JLFC (Autor) FMUP; Mota Pereira, J (Autor) Outra; Pimentel, P (Autor) Outra; Maia, D (Autor) Outra; Correia, D (Autor) Outra; Gomes, S (Autor) Outra; Cruz, A (Autor) Outra; Rui Medeiros (Autor) ICBAS

Revista

Título: Neuroscience Letters

Vol. 622

Páginas: 107-112

ISSN: 0304-3940

Editora: Elsevier

Indexação

ISI Web of Knowledge - 9 Citações

Scopus - 9 Citações

Outras Informações

ID Authenticus: P-00K-EYP

DOI: 10.1016/j.neulet.2016.03.026

Abstract (EN): Recent studies suggest that immune activation and cytokines, such as IL-18, are involved in depression. IL-18 is expressed in brain and is increased in patients with moderate to severe depression. In this study we aim to evaluate the role of ILI 8-607C>A and 1L18-137G>C promoter polymorphisms in antidepressant treatment phenotypes, specifically relapse and treatment resistant depression (TRD). We genotyped the referred polymorphisms in a subset of 80 MDD patients followed at Hospital Magalhaes Lemos, Portugal, within a period of 27 months. Patients carrying IL18-607 CA or AA genotypes were significantly more prone to relapse after AD treatment and present a significantly lower time to relapse than patients carrying CC genotype. Similarly, patients carrying IL18-137 GC or CC genotypes have a significantly higher risk of relapse and display relapse significantly earlier than the ones carrying GG genotype. Due to the low number of IL18-607 CC and IL18-137 GG in the relapse subgroup (n = 3 and n = 5, respectively), results were validated by bootstrapping analysis, and remained significant. No association was found between the evaluated genetic polymorphisms and TRD.IL18 peripheral mRNA levels were upregulated in IL18-607 CA or AA carriers. This preliminary report indicates that IL18-607C>A and IL18-137G>C genetic polymorphisms seem to influence depression relapse after antidepressant treatment in our subset of depressed patients, and may possibly contribute to the disregulated IL-18 levels found in patients with depression.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6