The role of IL18-607C > A and IL18-137G > C promoter polymorphisms in antidepressant treatment phenotypes: A preliminary report

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Santos, M (Author) Other; Carvalho, S (Author) Other; Lima, JLFC (Author) FMUP; Mota Pereira, J (Author) Other; Pimentel, P (Author) Other; Maia, D (Author) Other; Correia, D (Author) Other; Gomes, S (Author) Other; Cruz, A (Author) Other; Rui Medeiros (Author) ICBAS

Journal

Title: Neuroscience Letters

Vol. 622

Pages: 107-112

ISSN: 0304-3940

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 9 Citations

Scopus - 9 Citations

Other information

Authenticus ID: P-00K-EYP

DOI: 10.1016/j.neulet.2016.03.026

Abstract (EN): Recent studies suggest that immune activation and cytokines, such as IL-18, are involved in depression. IL-18 is expressed in brain and is increased in patients with moderate to severe depression. In this study we aim to evaluate the role of ILI 8-607C>A and 1L18-137G>C promoter polymorphisms in antidepressant treatment phenotypes, specifically relapse and treatment resistant depression (TRD). We genotyped the referred polymorphisms in a subset of 80 MDD patients followed at Hospital Magalhaes Lemos, Portugal, within a period of 27 months. Patients carrying IL18-607 CA or AA genotypes were significantly more prone to relapse after AD treatment and present a significantly lower time to relapse than patients carrying CC genotype. Similarly, patients carrying IL18-137 GC or CC genotypes have a significantly higher risk of relapse and display relapse significantly earlier than the ones carrying GG genotype. Due to the low number of IL18-607 CC and IL18-137 GG in the relapse subgroup (n = 3 and n = 5, respectively), results were validated by bootstrapping analysis, and remained significant. No association was found between the evaluated genetic polymorphisms and TRD.IL18 peripheral mRNA levels were upregulated in IL18-607 CA or AA carriers. This preliminary report indicates that IL18-607C>A and IL18-137G>C genetic polymorphisms seem to influence depression relapse after antidepressant treatment in our subset of depressed patients, and may possibly contribute to the disregulated IL-18 levels found in patients with depression.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6