SUBSTITUTED XANTHONES AS SELECTIVE AND REVERSIBLE MONOAMINE OXIDASE-A (MAO-A) INHIBITORS

• Tipo: Artigo em Revista Científica Internacional
• Data: 1993

Autores

THULL, U (Autor) Outra; KNEUBUHLER, S (Autor) Outra; TESTA, B (Autor) Outra; BORGES, MFM (Autor) FFUP; PINTO, MMM (Autor) FFUP

Revista

Título: Pharmaceutical Research

Vol. 10

ISSN: 0724-8741

Editora: Springer Nature

Indexação

ISI Web of Knowledge - 37 Citações

Scopus - 43 Citações

Classificação Científica

FOS: Ciências exactas e naturais > Química

Outras Informações

ID Authenticus: P-001-MV4

Abstract (EN): 1,3-Dihydroxy-2-methylxanthone (X1), its 4-chloro and 4-bromo derivatives (X1-Cl and X1-Br), and 1,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. The compounds proved to be reversible and selective inhibitors of MAO-A, with X1 displaying the highest activity (IC50 = 3.7 muM).

Idioma: Inglês

Tipo (Avaliação Docente): Científica