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SUBSTITUTED XANTHONES AS SELECTIVE AND REVERSIBLE MONOAMINE OXIDASE-A (MAO-A) INHIBITORS

Title
SUBSTITUTED XANTHONES AS SELECTIVE AND REVERSIBLE MONOAMINE OXIDASE-A (MAO-A) INHIBITORS
Type
Article in International Scientific Journal
Year
1993
Authors
THULL, U
(Author)
Other
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KNEUBUHLER, S
(Author)
Other
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TESTA, B
(Author)
Other
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BORGES, MFM
(Author)
FFUP
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PINTO, MMM
(Author)
FFUP
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Journal
Vol. 10
ISSN: 0724-8741
Publisher: Springer Nature
Scientific classification
FOS: Natural sciences > Chemical sciences
Other information
Authenticus ID: P-001-MV4
Abstract (EN): 1,3-Dihydroxy-2-methylxanthone (X1), its 4-chloro and 4-bromo derivatives (X1-Cl and X1-Br), and 1,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. The compounds proved to be reversible and selective inhibitors of MAO-A, with X1 displaying the highest activity (IC50 = 3.7 muM).
Language: English
Type (Professor's evaluation): Scientific
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