Thyroid hormone as a regulator of tumor induced angiogenesis

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2011

Autores

Marta Pinto (Autor) Outra; Paula Soares (Autor) FMUP; Domenico Ribatti (Autor) Outra

Revista

Título: Cancer Letters

Vol. 301

Páginas: 119-126

ISSN: 0304-3835

Editora: Elsevier

Indexação

ISI Web of Knowledge - 47 Citações

Scopus - 56 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina clínica

Outras Informações

ID Authenticus: P-002-V24

DOI: 10.1016/j.canlet.2010.11.011

Abstract (EN): Thyroid hormones (TH) - 3,5,3`-triiodo-L-thyronine (T(3)) and L-thyroxine (T(4)) - are important regulators of differentiation, growth, metabolism, and physiological function in most tissues. TH have been also implicated in cellular transformation, tumorigenesis and metastasis, assuming particular importance in tumor induced angiogenesis. TH-induced angiogenesis is thought to be initiated at integrin alpha v beta 3 membrane receptor mainly through T(4) binding. The reduction of TH in circulation or the inhibition of TH actions at the integrin alpha v beta 3 receptor would consequently produce a reduction on the proliferative and angiogenic TH effects. Therefore, targeting TH actions could be an alternative adjuvant therapy against cancer proliferation and angiogenesis.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 8