Thyroid hormone as a regulator of tumor induced angiogenesis

• Type: Another Publication in an International Scientific Journal
• Date: 2011

Authors

Marta Pinto (Author) Other; Paula Soares (Author) FMUP; Domenico Ribatti (Author) Other

Journal

Title: Cancer Letters

Vol. 301

Pages: 119-126

ISSN: 0304-3835

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 51 Citations

Scopus - 57 Citations

Scientific classification

FOS: Medical and Health sciences > Clinical medicine

Other information

Authenticus ID: P-002-V24

DOI: 10.1016/j.canlet.2010.11.011

Abstract (EN): Thyroid hormones (TH) - 3,5,3`-triiodo-L-thyronine (T(3)) and L-thyroxine (T(4)) - are important regulators of differentiation, growth, metabolism, and physiological function in most tissues. TH have been also implicated in cellular transformation, tumorigenesis and metastasis, assuming particular importance in tumor induced angiogenesis. TH-induced angiogenesis is thought to be initiated at integrin alpha v beta 3 membrane receptor mainly through T(4) binding. The reduction of TH in circulation or the inhibition of TH actions at the integrin alpha v beta 3 receptor would consequently produce a reduction on the proliferative and angiogenic TH effects. Therefore, targeting TH actions could be an alternative adjuvant therapy against cancer proliferation and angiogenesis.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 8