HYPOTHERMIA INDUCES SUPERSENSITIVITY OF MOUSE VAS-DEFERENS TO ADRENERGIC AGONISTS - EVIDENCE FOR POSTJUNCTIONAL ALPHA-2-ADRENOCEPTORS

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 1989

Autores

GONCALVES, J (Autor) FFUP; PROENCA, J (Autor) Outra; ALBUQUERQUE, AA (Autor) Outra; PAIVA, MQ (Autor) Outra

Revista

Título: Journal of Pharmacy and Pharmacology

Vol. 41

Páginas: 52-54

ISSN: 0022-3573

Editora: Oxford University Press

Indexação

ISI Web of Knowledge - 8 Citações

Scopus - 8 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-001-SYN

Abstract (EN): Hypothermia-induced potentiation of ¿-adrenoceptor-mediated responses of the mouse vas deferens to noradrenaline is mainly caused by inhibition of the sites of loss. However, even after blockade of the sites of loss for noradrenaline or when using methoxamine (which is not a substrate for uptake or metabolism) hypothermia still causes a significant increase in responsiveness. This remaining supersensitivity was shown to be an increased receptor affinity. Furthermore, hypothermia revealed contractile responses to low concentrations of UK 14304 (an ¿2-agonist).

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 3