HYPOTHERMIA INDUCES SUPERSENSITIVITY OF MOUSE VAS-DEFERENS TO ADRENERGIC AGONISTS - EVIDENCE FOR POSTJUNCTIONAL ALPHA-2-ADRENOCEPTORS

• Type: Another Publication in an International Scientific Journal
• Date: 1989

Authors

GONCALVES, J (Author) FFUP; PROENCA, J (Author) Other; ALBUQUERQUE, AA (Author) Other; PAIVA, MQ (Author) Other

Journal

Title: Journal of Pharmacy and Pharmacology

Vol. 41

Pages: 52-54

ISSN: 0022-3573

Publisher: Oxford University Press

Indexing

ISI Web of Knowledge - 8 Citations

Scopus - 8 Citations

Scientific classification

FOS: Medical and Health sciences > Basic medicine

Other information

Authenticus ID: P-001-SYN

Abstract (EN): Hypothermia-induced potentiation of ¿-adrenoceptor-mediated responses of the mouse vas deferens to noradrenaline is mainly caused by inhibition of the sites of loss. However, even after blockade of the sites of loss for noradrenaline or when using methoxamine (which is not a substrate for uptake or metabolism) hypothermia still causes a significant increase in responsiveness. This remaining supersensitivity was shown to be an increased receptor affinity. Furthermore, hypothermia revealed contractile responses to low concentrations of UK 14304 (an ¿2-agonist).

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 3