Abstract (EN):
Hypothermia-induced potentiation of ¿-adrenoceptor-mediated responses of the mouse vas deferens to noradrenaline is mainly caused by inhibition of the sites of loss. However, even after blockade of the sites of loss for noradrenaline or when using methoxamine (which is not a substrate for uptake or metabolism) hypothermia still causes a significant increase in responsiveness. This remaining supersensitivity was shown to be an increased receptor affinity. Furthermore, hypothermia revealed contractile responses to low concentrations of UK 14304 (an ¿2-agonist).
Idioma:
Inglês
Tipo (Avaliação Docente):
Científica
Nº de páginas:
3