Biomaterials

Code:

EBE0118

Acronym:

BIOM

Keywords
Classification	Keyword
OFICIAL	Biomedical Engineering

Instance: 2020/2021 - 2S

Active?	Yes
Responsible unit:	Department of Metallurgical and Materials Engineering
Course/CS Responsible:	Master in Bioengineering

Cycles of Study/Courses

Acronym	No. of Students	Study Plan	Curricular Years	Credits UCN	Credits ECTS	Contact hours	Total Time
MIB	38	Syllabus	3	-	6	56	162

Teaching language

English

Objectives

To provide fundamental principles on Biomaterials Science and Engineering and state of the art knowledge on biomaterials development, in particular for the most relevant medical applications. Since the interaction between biomaterials and tissues is a critical aspect in the performance of biomaterials, the course will cover several of its facets, including the dialogue with the microenvironment and its cellular and extracellular components. The new generation biomaterials designed at the molecular level, using nanotechnology approaches, will be also covered in depth. Their application in regenerative medicine will also be highlighted.

 

 

 

 

 

Learning outcomes and competences

This subject will provide to the students from MIB  the capacities to have essential knowledge on Biomaterials, allowing them to do adequate choices, to introduce changes and performance improvements or to be able to produce them od characterize them in the adequate context, based on physical and mechanical properties , as well as chemical and surface characterisitics and the biological  implications for the host tissues that interact with them.

Working method

Presencial

Program

- Fundamental principles of Biomaterials. The evolution of biomaterials and implantable medical devices. Degradable and non-degradable biomaterials. Clinical applications and complications. Medical applications in tissue repair, replacement and regeneration.

- Metallic biomaterials. Bioceramics and Bio-glass and ceramic-based cements. Synthetic and biodegradable biopolymers. Natural polymers. Degradation of biomaterials: mechanisms; the pros and cons of degradation.

- Disinfection and sterilization of medical devices. Biocompatibility Assessment (ISO 10993). Regulatory studies

Mandatory literature

Ratner, Buddy D. 340; Biomaterials science. ISBN: 0-12-582463-7
Dee, Key C.; An Introduction to tissue-biomaterial interactions. ISBN: 0-471-25394-4
Di Silvio, L.; Cellular Response to Biomaterials, Woodhead Publishing in Materials, 2009. ISBN: 978-1420093735
Atala, A.; Foundations of Regenerative Medicine: Clinical and Therapeutic Applications, Academic Press, 2009. ISBN: 978-0123750853

Teaching methods and learning activities

The key aspects of each topic will be presented first by the lecturer. This will be followed by a thorough discussion in subsequent classes and presentation of critical examples by the students, resulting from a literature search. The discussion may be led by one to three students and can be kicked-off by a brief presentation (typically 10 min).

Evaluation Type

Distributed evaluation with final exam

Assessment Components

Designation	Weight (%)
Exame	70,00
Trabalho laboratorial	30,00
Total:	100,00

Amount of time allocated to each course unit

Designation	Time (hours)
Frequência das aulas	75,00
Trabalho laboratorial	25,00
Total:	100,00

Eligibility for exams

The student must have taken an active role in the theoretical-practical review work and obtain in it a minimum mark of 6.0/20.

Calculation formula of final grade

The knowledge assessment related to the TP component has a weight of 70% and the PL component has a weight of 30%

In the TP component, the Assessment is distributed without a final exam. Students perform an intermediate knowledge assessment test related to the training acquired in class, with a weight of 70% (TP1), and must submit and present a report related to a theoretical and practical study of a topic that is proposed to them and whose weight is 30% (PL). The evaluation of this component includes three parts: the evaluation by the teachers of the work and the respective presentation by the group (TP2, 20%), the evaluation of each student by their peers in the group (TP3, 8%) and the evaluation of each student regarding all other groups (TP4, 2%).
The evaluation of the PL component will be carried out through a test related to the knowledge acquired in the PL classes.

Final grade = 0.30 * PL + 0.70 * (70% TP1 + 20% TP2 + 8% TP3 + 2% TP4)

Examinations or Special Assignments

Not applicable.

Special assessment (TE, DA, ...)

As specified by the rules applicable to the Mestrado Integrado em Bioengenharia.

Classification improvement

As specified by the rules applicable to the Mestrado Integrado em Bioengenharia.

Observations

TP and PL classes were held in person until the 13th of March and later, due to COVID-19, they were taught at a distance (Zoom and Moodle).

The evaluation of both components has been changed.

The TP component assessment consists of two components: written group work with oral defence (Zoom platform) and a 90-minute written exam at FEUP.

The PL component is assessed through quizzes (Moodle).

Final evaluation = 0.15 * PL grade + 0.85 * TP grade

Grade TP = 0.40 * Grade Group work + 0.60 * Grade Written exam

Grade PL = average of quizzes, excluding the quiz with the lowest grade