NRAMP1-or cytokine-induced bacteriostasis of Mycobacterium avium by mouse macrophages is independent of the respiratory burst

• Type: Article in International Scientific Journal
• Date: 2002

Authors

Gomes, MS (Author) ICBAS; Appelberg, R (Author) ICBAS

Journal

Title: Microbiology

Vol. 148

Pages: 3155-3160

ISSN: 1350-0872

Publisher: Microbiological Society

Indexing

ISI Web of Knowledge - 24 Citations

Scopus - 28 Citations

Pubmed / Medline

Scientific classification

FOS: Natural sciences > Biological sciences

CORDIS: Health sciences > Medical sciences > Medicine > Infections

Other information

Authenticus ID: P-000-MWD

Abstract (EN): Restriction of the growth of Mycobacterium avium was studied in wild-type and p47(phox)-deficient macrophages. The ability of gamma interferon and tumour necrosis factor alpha to induce anti mycobacteria I activity in bone-marrow-derived macrophages or the expression of the NRAMP1-mediated resistance to M. avium were not affected by the deficiency in p47(phox). The addition of exogenous iron increased mycobacterial growth in macrophages expressing a functional NRAMP1 protein or a mutant NRAMP1 protein. Reactive oxygen species are therefore not involved in the constitutive or induced anti-M. avium activities of the mouse macrophage.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 6