NRAMP1-or cytokine-induced bacteriostasis of Mycobacterium avium by mouse macrophages is independent of the respiratory burst

• Tipo: Artigo em Revista Científica Internacional
• Data: 2002

Autores

Gomes, MS (Autor) ICBAS; Appelberg, R (Autor) ICBAS

Revista

Título: Microbiology

Vol. 148

Páginas: 3155-3160

ISSN: 1350-0872

Editora: Microbiological Society

Indexação

ISI Web of Knowledge - 24 Citações

Scopus - 28 Citações

Pubmed / Medline

Classificação Científica

FOS: Ciências exactas e naturais > Ciências biológicas

CORDIS: Ciências da Saúde > Ciências Médicas > Medicina > Infecções

Outras Informações

ID Authenticus: P-000-MWD

Abstract (EN): Restriction of the growth of Mycobacterium avium was studied in wild-type and p47(phox)-deficient macrophages. The ability of gamma interferon and tumour necrosis factor alpha to induce anti mycobacteria I activity in bone-marrow-derived macrophages or the expression of the NRAMP1-mediated resistance to M. avium were not affected by the deficiency in p47(phox). The addition of exogenous iron increased mycobacterial growth in macrophages expressing a functional NRAMP1 protein or a mutant NRAMP1 protein. Reactive oxygen species are therefore not involved in the constitutive or induced anti-M. avium activities of the mouse macrophage.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 6