Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?

• Type: Another Publication in an International Scientific Journal
• Date: 2021

Authors

Jain, S (Author) Other; Santana, W (Author) Other; Dolabella, SS (Author) Other; Santos, ALS (Author) Other; Souto, EB (Author) Other; Severino, P (Author) Other

Journal

Title: Pharmaceutics

Vol. 13

Final page: 491

ISSN: 1999-4923

Publisher: MDPI

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 2 Citations

Scientific classification

CORDIS: Health sciences

Other information

Authenticus ID: P-00T-VKH

DOI: 10.3390/pharmaceutics13040491

Abstract (EN): Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 19