Are Nanobiosensors an Improved Solution for Diagnosis of Leishmania?

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2021

Autores

Jain, S (Autor) Outra; Santana, W (Autor) Outra; Dolabella, SS (Autor) Outra; Santos, ALS (Autor) Outra; Souto, EB (Autor) Outra; Severino, P (Autor) Outra

Revista

Título: Pharmaceutics

Vol. 13

Página Final: 491

ISSN: 1999-4923

Editora: MDPI

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 2 Citações

Classificação Científica

CORDIS: Ciências da Saúde

Outras Informações

ID Authenticus: P-00T-VKH

DOI: 10.3390/pharmaceutics13040491

Abstract (EN): Leishmaniasis is one of the deadliest neglected tropical diseases affecting 12-15 million people worldwide, especially in middle- and low-income countries. Rapid and accurate diagnosis of the disease is important for its adequate management and treatment. Several techniques are available for the diagnosis of leishmaniasis. Among these, parasitological and immunological tests are most widely used. However, in most cases, the utilized diagnostic techniques are not good enough, showing cross-reactivity and reduced accuracy. In recent years, many new methods have been reported with potential for improved diagnosis. This review focuses on the diagnosis of Leishmania exploring the biosensors and nanotechnology-based options for their detection. New developments including the use of nanomaterials as fluorophores, fluorescence quenchers as reducing agents and as dendrimers for signal improvement and amplification, together with the use of aptamers to replace antibodies are described. Future research opportunities to overcome the current limitations on the available diagnostic approaches are also discussed.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 19