Combining repurposed drugs to treat colorectal cancer

• Type: Another Publication in an International Scientific Journal
• Date: 2022

Authors

Duarte, D (Author) Other; Nuno Vale (Author) FMUP

Journal

Title: Drug Discovery Today

Vol. 27

Pages: 165-184

ISSN: 1359-6446

Publisher: Elsevier

Indexing

ISI Web of Knowledge - 0 Citations

Scopus - 0 Citations

Other information

Authenticus ID: P-00V-EEB

DOI: 10.1016/j.drudis.2021.09.012

Abstract (EN): The drug development process, especially of antineoplastic agents, has become increasingly costly and ineffective. Drug repurposing and drug combination are alternatives to de novo drug development, being low cost, rapid, and easy to apply. These strategies allow higher efficacy, decreased toxicity, and overcoming of drug resistance. The combination of antineoplastic agents is already being applied in cancer therapy, but the combination of repurposed drugs is still under-explored in pre- and clinical development. In this review, we provide a set of pharmacological concepts focusing on drug repurposing for treating colorectal cancer (CRC) and that are relevant for the application of new drug combinations against this disease.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 20