Combining repurposed drugs to treat colorectal cancer

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2022

Autores

Duarte, D (Autor) Outra; Nuno Vale (Autor) FMUP

Revista

Título: Drug Discovery Today

Vol. 27

Páginas: 165-184

ISSN: 1359-6446

Editora: Elsevier

Indexação

ISI Web of Knowledge - 0 Citações

Scopus - 0 Citações

Outras Informações

ID Authenticus: P-00V-EEB

DOI: 10.1016/j.drudis.2021.09.012

Abstract (EN): The drug development process, especially of antineoplastic agents, has become increasingly costly and ineffective. Drug repurposing and drug combination are alternatives to de novo drug development, being low cost, rapid, and easy to apply. These strategies allow higher efficacy, decreased toxicity, and overcoming of drug resistance. The combination of antineoplastic agents is already being applied in cancer therapy, but the combination of repurposed drugs is still under-explored in pre- and clinical development. In this review, we provide a set of pharmacological concepts focusing on drug repurposing for treating colorectal cancer (CRC) and that are relevant for the application of new drug combinations against this disease.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20