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The Bioactivity of Pomegranate: Impact on Health and Disease

Title
The Bioactivity of Pomegranate: Impact on Health and Disease
Type
Another Publication in an International Scientific Journal
Year
2011
Authors
Ana Faria
(Author)
FCUP
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Conceicao Calhau
(Author)
FMUP
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Journal
Vol. 51 No. 7
Pages: 626-634
ISSN: 1040-8398
Publisher: Taylor & Francis
Indexing
Publicação em ISI Web of Science ISI Web of Science
Pubmed / Medline
Scientific classification
FOS: Agrarian Sciences > Other Agrarian Sciences
CORDIS: Health sciences > Pharmacological sciences
Other information
Authenticus ID: P-002-YA2
Abstract (EN): The aim of the present review is to discuss the cumulative evidence that suggests that pomegranate consumption possesses a diverse array of biological actions and may be helpful in the prevention of some inflammatory-mediated diseases including cancer. The pomegranate fruit can be divided into at least three parts-seeds, peel, and juice. All these components have been studied for their antioxidant properties in a chemoprevention approach. Pomegranate exerts antiproliferative, anti-invasive, and antimetastatic effects, induces apoptosis through modulation of Bcl-2 proteins, increases p21 and p27, and downregulates cyclin-cdk network. In addition, pomegranate inhibits the activation of inflammatory pathways including, but not limited to, the NF kappa-B pathway. Anti-cancer effects with the most impressive data have been demonstrated so far in prostate cancer.
Language: English
Type (Professor's evaluation): Scientific
Contact: anafaria@med.up.pt
Notes: <a href="http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Alerting&SrcApp=Alerting&DestApp=WOS&DestLinkType=FullRecord&KeyUT=000293839700004 ">Indexado na Web of Science</a> Epub 2011 Mai 06
No. of pages: 9
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