Resumo (PT):
Abstract (EN):
Red blood cells (RBCs) in microchannels has tendency to undergo axial migration due to
the parabolic velocity profile, which results in a high
shear stress around wall that forces the RBC to move
towards the centre induced by the tank treading motion
of the RBC membrane. As a result there is a formation
of a cell free layer (CFL) with extremely low concentration of cells. Based on this phenomenon, several
works have proposed microfluidic designs to separate
the suspending physiological fluid from whole in vitro blood. This study aims to characterize the CFL in
hyperbolic-shaped microchannels to separate RBCs
from plasma. For this purpose, we have investigated
the effect of hyperbolic contractions on the CFL by
using not only different Hencky strains but also varying the series of contractions. The results show that the
hyperbolic contractions with a Hencky strain of 3 and
higher, substantially increase the CFL downstream of
the contraction region in contrast with the microchannels with a Hencky strain of 2, where the effect is insignificant. Although, the highest CFL thickness occur
at microchannels with a Hencky strain of 3.6 and 4.2
the experiments have also shown that cells blockage
are more likely to occur at this kind of microchannels.
Hence, the most appropriate hyperbolic-shaped microchannels to separate RBCs from plasma is the one with
a Hencky strain of 3.
Idioma:
Inglês
Tipo (Avaliação Docente):
Científica
Nº de páginas:
7