Magnetoliposomes based on manganese ferrite nanoparticles as nanocarriers for antitumor drugs

• Tipo: Artigo em Revista Científica Internacional
• Data: 2016

Autores

Rodrigues, ARO (Autor) Outra; Ramos, JMF (Autor) Outra; Gomes, IT (Autor) Outra; Almeida, BG (Autor) Outra; araujo, j. p. (Autor) FCUP; Queiroz, MJRP (Autor) Outra; Coutinho, PJG (Autor) Outra; Castanheira, EMS (Autor) Outra

Revista

Título: RSC Advances

Vol. 6

Páginas: 17302-17313

ISSN: 2046-2069

Editora: Royal Society of Chemistry

Indexação

ISI Web of Knowledge - 37 Citações

Scopus - 39 Citações

Outras Informações

ID Authenticus: P-00K-6V9

DOI: 10.1039/c5ra27058h

Abstract (EN): Manganese ferrite nanoparticles with a size distribution of 26 +/- 7 nm (from TEM measurements) were synthesized by the coprecipitation method. The obtained nanoparticles exhibit a superparamagnetic behaviour at room temperature with a magnetic squareness of 0.016 and a coercivity field of 6.3 Oe. These nanoparticles were either entrapped in liposomes (aqueous magnetoliposomes, AMLs) or covered with a lipid bilayer, forming solid magnetoliposomes (SMLs). Both types of magnetoliposomes, exhibiting sizes below or around 150 nm, were found to be suitable for biomedical applications. Membrane fusion between magnetoliposomes (both AMLS and SMLs) and GUVs (giant unilamellar vesicles), the latter used as models of cell membranes, was confirmed by Forster Resonance Energy Transfer (FRET) assays, using a NBD labeled lipid as the energy donor and Nile Red or rhodamine B-DOPE as the energy acceptor. A potential antitumor thienopyridine derivative was successfully incorporated into both aqueous and solid magnetoliposomes, pointing to a promising application of these systems in oncological therapy, simultaneously as hyperthermia agents and nanocarriers for antitumor drugs.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 12