Magnetoliposomes based on manganese ferrite nanoparticles as nanocarriers for antitumor drugs

• Type: Article in International Scientific Journal
• Date: 2016

Authors

Rodrigues, ARO (Author) Other; Ramos, JMF (Author) Other; Gomes, IT (Author) Other; Almeida, BG (Author) Other; araujo, j. p. (Author) FCUP; Queiroz, MJRP (Author) Other; Coutinho, PJG (Author) Other; Castanheira, EMS (Author) Other

Journal

Title: RSC Advances

Vol. 6

Pages: 17302-17313

ISSN: 2046-2069

Publisher: Royal Society of Chemistry

Indexing

ISI Web of Knowledge - 37 Citations

Scopus - 39 Citations

Other information

Authenticus ID: P-00K-6V9

DOI: 10.1039/c5ra27058h

Abstract (EN): Manganese ferrite nanoparticles with a size distribution of 26 +/- 7 nm (from TEM measurements) were synthesized by the coprecipitation method. The obtained nanoparticles exhibit a superparamagnetic behaviour at room temperature with a magnetic squareness of 0.016 and a coercivity field of 6.3 Oe. These nanoparticles were either entrapped in liposomes (aqueous magnetoliposomes, AMLs) or covered with a lipid bilayer, forming solid magnetoliposomes (SMLs). Both types of magnetoliposomes, exhibiting sizes below or around 150 nm, were found to be suitable for biomedical applications. Membrane fusion between magnetoliposomes (both AMLS and SMLs) and GUVs (giant unilamellar vesicles), the latter used as models of cell membranes, was confirmed by Forster Resonance Energy Transfer (FRET) assays, using a NBD labeled lipid as the energy donor and Nile Red or rhodamine B-DOPE as the energy acceptor. A potential antitumor thienopyridine derivative was successfully incorporated into both aqueous and solid magnetoliposomes, pointing to a promising application of these systems in oncological therapy, simultaneously as hyperthermia agents and nanocarriers for antitumor drugs.

Language: English

Type (Professor's evaluation): Scientific

No. of pages: 12