Mechanisms Underlying the Hepatotoxic Effects of Ecstasy

• Tipo: Outra Publicação em Revista Científica Internacional
• Data: 2010

Autores

Marcia Carvalho (Autor) Outra; Helena Pontes (Autor) Outra; Fernando Remiao (Autor) FFUP; Maria L Bastos (Autor) FFUP; Felix Carvalho (Autor) FFUP

Revista

Título: Current Pharmaceutical Biotechnology

Vol. 11

Páginas: 476-495

ISSN: 1389-2010

Editora: Bentham Science

Indexação

ISI Web of Knowledge - 38 Citações

Scopus - 51 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Medicina básica

Outras Informações

ID Authenticus: P-003-46Y

DOI: 10.2174/138920110791591535

Abstract (EN): 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy) is a worldwide illegally used amphetamine-derived designer drug known to be hepatotoxic to humans. Jaundice, hepatomegaly, centrilobular necrosis, hepatitis and fibrosis represent some of the adverse effects caused by MDMA in the liver. Although there is irrefutable evidence of MDMA-induced hepatocellular damage, the mechanisms responsible for that toxicity remain to be thoroughly clarified. One well thought-of mechanism imply MDMA metabolism in the liver into reactive metabolites as responsible for the MDMA-elicited hepatotoxicity. However, other factors, including MDMA-induced hyperthermia, the increase in neurotransmitters efflux, the oxidation of biogenic amines, polydrug abuse pattern, and environmental features accompanying illicit MDMA use, may increase the risk for liver complications. Liver damage patterns of MDMA in animals and humans and current research on the mechanisms underlying the hepatotoxic effects of MDMA will be highlighted in this review.

Idioma: Inglês

Tipo (Avaliação Docente): Científica

Nº de páginas: 20