Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues

• Tipo: Artigo em Revista Científica Internacional
• Data: 2013

Autores

Bianca C Perez (Autor) Outra; Iva Fernandes (Autor) FCUP; Nuno Mateus (Autor) FCUP; Catia Teixeira (Autor) Outra; Paula Gomes (Autor) FCUP

Revista

Título: Bioorganic and Medicinal Chemistry Letters

Vol. 23

Páginas: 6769-6772

ISSN: 0960-894X

Editora: Elsevier

Indexação

ISI Web of Knowledge - 12 Citações

Scopus - 12 Citações

Classificação Científica

FOS: Ciências médicas e da saúde > Ciências da saúde

Outras Informações

ID Authenticus: P-006-J4T

DOI: 10.1016/j.bmcl.2013.10.025

Abstract (EN): Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28, Caco-2, and MCF-7. All compounds display anti-proliferative activity in the micromolar range against the three cell lines tested, and most of them were more active than their parent drug, chloroquine, against all cell lines tested. Hence, N-cinnamoyl-chloroquine analogues are a good start towards development of affordable antitumor leads.

Idioma: Inglês

Tipo (Avaliação Docente): Científica